Author

Mya S. Wolfe

National Institutes of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Megha RajendraniD· 3 shared Sergey M. BezrukoviD· 3 shared Tatiana K. RostovtsevaiD· 3 shared Bethel G. BeyeneiD· 2 shared Motahareh Ghahari LarimiiD· 2 shared Nina A. Bautista· 2 shared Wendy FitzgeraldiD· 2 shared Alexander J. SodtiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersBiophysics

Megha RajendranORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

So similar, yet so different: α-synuclein recognition of the isoform-specific VDAC protein-lipid interface

Tatiana K. Rostovtseva, Megha Rajendran, William M. Rosencrans, María Queralt-Martín, Mya S. Wolfe, Nina A. Bautista, Bethel G. Beyene, Motahareh Ghahari Larimi, Alexander J. Sodt, Sergey M. Bezrukov

The paper investigates how α-synuclein interacts differently with VDAC isoforms by analyzing binding kinetics and translocation behavior in planar lipid membranes.

bioRxiv · Oct 19, 2026 · PreprintBiophysics

Identifying Novel Estrogenic Mitochondrial Targets in Hypothalamic Proopiomelanocortin Neurons by Chemoproteomics

Jian Qiu, Martha A. Bosch, Mya S. Wolfe, Ksenija Korać, Stefano Rizzo, Todd L. Stincic, Scotland E. Farley, Wendy Fitzgerald, Megha Rajendran, Aurélien Laguerre, Frank Stein, Philip F. Copenhaver, Oline K. Rønnekleiv, Sean M. Ronnekleiv‐Kelly, Tatiana K. Rostovtseva, , Martin J. Kelly

This study identifies STX, a non-steroidal estrogenic compound, as targeting mitochondrial VDAC2 to enhance bioenergetics and provide neuroprotection in hypothalamic POMC neurons.

bioRxiv · Aug 21, 2026 · PreprintNeuroscience

A Membrane-Disruptive Action of VBIT-4 Challenges Its Role as a Widely Used VDAC Oligomerization Inhibitor

Varun Ravishankar, Luís Borges-Araújo, Megha Rajendran, Elodie Lafargue, Deborah Byrne, Nicolas Buzhinsky, Mya S. Wolfe, Wendy Fitzgerald, Nina A. Bautista, Bethel G. Beyene, Motahareh Ghahari Larimi, Jean‐Pierre Duneau, James N. Sturgis, Sergey M. Bezrukov, Ignacio I. Casuso, , Lucie A. Bergdoll

This paper shows that VBIT-4 disrupts mitochondrial membranes and causes cytotoxicity, challenging its role as a VDAC1 oligomerization inhibitor.

bioRxiv · Jun 30, 2025 · PreprintBiochemistry