Avery C. Hunker

The paper presents a barcoded multiplex strategy to screen enhancer AAVs using single-cell RNA sequencing and taxonomy mapping, but finds significant technical and biological noise complicates accurate expression pattern analysis.

The paper develops a cross-species enhancer-AAV toolkit for targeting specific cell types in the basal ganglia across species, validated in mouse and macaque.

The paper analyzes multi-modal Patch-seq data from macaque striatum to reveal morphoelectric diversity and functional specialization of neuronal cell types, highlighting primate-specific features and differences from rodents.

The paper presents an enhancer AAV toolbox for targeting and perturbing striatal cell types and circuits in mice, with validated specificity and cross-species applicability.

The paper develops a toolkit of transgenic mouse lines and enhancer AAVs for selective targeting of cortical cell populations using transcriptomic and epigenomic data.

This study compares AAV9 and AAV-PHP.eB transduction efficiency in pigtail macaques, finding AAV-PHP.eB achieves higher rates in cortical and spinal regions.

The paper shows that AAV libraries packaged as pools exhibit extensive chimerism due to length and homology dependence, affecting most genomes.

This study investigates the role of dopamine D2 receptors in the bed nucleus of the stria terminalis (BNST) in modulating alcohol-related behaviors in male and female mice, finding sex-specific effects on alcohol consumption and pain sensitivity.

This study shows that VTA glutamate neurons can drive reward through glutamate release and aversion through dopamine co-release using optogenetic manipulation.

This study shows that Kv4.3 and BKCa1.1 ion channels regulate dopamine neuron firing and release on different time scales, influencing distinct phases of reinforced behavior in mice.

This study shows that the FAAH C385A polymorphism exacerbates hormone-mediated feeding in mice under specific environmental conditions, affecting metabolic outcomes.

This study shows that netrin-1 maintains excitatory connectivity in the adult ventral tegmental area, with imbalances affecting behavior.

The paper develops two genetically encoded tools to monitor and silence neuropeptide release in vivo, revealing neuropeptides, not glutamate, as the primary transmitter in Pavlovian threat learning.

The paper identifies KOR/Dyn signaling in the midbrain as promoting threat generalization, showing an inverted U relationship between threat intensity and discrimination.

This study identifies an endogenous opioid circuit in mice that regulates appetitive behavior through a dorsal raphe to nucleus accumbens projection.

This study uses CRISPR to knock down Kcnq3 in NPY/AgRP neurons, reducing the M-current and increasing neuronal excitability without affecting ingestive behavior but decreasing locomotor activity.