Increased Nuclear Susceptibility to Mechanical Stress in Phospholamban R14del Cardiomyopathy: A New Perspective on Disease Heterogeneity
Jort S.A. van der Geest, Atze van der Pol, Leon H.L. Hermans, Achmed H.S. Al-Khaqani, Jeroen I.M. van Asten, Marlinne A.M.E. van Roessel, Willem B. van Ham, Anneline S.J.M. te Riele, Alain van Mil, Vasco Sampaio‐Pinto, Pieter A. Doevendans, Zhiyong Lei, Vito Conte, Joost P. G. Sluijter, Carlijn V. C. Bouten
This study shows that the PLN R14del mutation increases nuclear susceptibility to mechanical stress in cardiomyopathy, linking nuclear dysfunction to disease variability.
bioRxiv · Oct 27, 2026 · PreprintCell Biology