Alain van Mil

This study shows that the PLN R14del mutation increases nuclear susceptibility to mechanical stress in cardiomyopathy, linking nuclear dysfunction to disease variability.

The paper develops a cardiac spheroid model with monocytes to better mimic heart failure responses, showing improved functional and transcriptional changes compared to models without immune cells.

This study identifies picornavirus proteins that inhibit de novo nucleotide synthesis during infection using metabolomics and recombinant virus analysis.

This paper develops BCMA CAR T cells with a granzyme B-NOXA fusion to enhance apoptosis in multiple myeloma cells, improving killing efficacy in vitro and in xenograft models.

This study performs a large GWAS on dilated cardiomyopathy, identifying two new loci and confirming two existing ones, with potential therapeutic implications.

The paper investigates epigenetic and transcriptional changes in PLN R14del cardiomyopathy, identifying disrupted lipid metabolism and altered gene regulation.