Pieter A. Doevendans

This study shows that the PLN R14del mutation increases nuclear susceptibility to mechanical stress in cardiomyopathy, linking nuclear dysfunction to disease variability.

This paper introduces NEO-AAV, an engineered AAV platform that enhances T cell transduction and CAR-T cell generation by enveloping AAV in extracellular vesicles, improving immune resistance and transduction efficiency.

This paper introduces a platform for efficient protein delivery using extracellular vesicles engineered with biogenesis-inspired features, achieving functional gene editing in vitro and in vivo.

The paper investigates epigenetic and transcriptional changes in PLN R14del cardiomyopathy, identifying disrupted lipid metabolism and altered gene regulation.