Systems BiologyDiabetesPeer-reviewed
Bromodomain inhibition reveals FGF15/19 as a target of epigenetic regulation and metabolic control
Chisayo Kozuka, Vissarion Efthymiou, Vicência Sales…·Mary‐Elizabeth Patti
The paper shows that inhibiting bromodomain proteins like BRD4 reduces FGF15/19 expression, leading to hyperglycemia, and that overexpressing FGF19 can reverse these effects.