Darleen A. Sandoval

This study identifies SEL1L-HRD1 ERAD as a regulator of PC2 maturation and glucagon production in islet α cells by degrading misfolded proPC2.

This study uses single-cell transcriptomics to analyze how vertical sleeve gastrectomy affects intestinal epithelial cell types and pathways in mice, identifying gene and pathway changes related to metabolic improvements.

The paper identifies synergistic effects of multiple NTS neuron populations in suppressing food intake but shows they are not essential for the response to vertical sleeve gastrectomy.

The paper shows that inhibiting bromodomain proteins like BRD4 reduces FGF15/19 expression, leading to hyperglycemia, and that overexpressing FGF19 can reverse these effects.

This study identifies RIP-Cre25Mgn neurons expressing leptin receptors as critical for leptin's anti-dyslipidemia and glucose-lowering effects in insulin-deficient mice.