Author

Christopher M. Mulla

Joslin Diabetes Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Systems Biology· 1

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Chisayo KozukaiD· 1 shared Cristina Aguayo‐MazzucatoiD· 1 shared Darleen A. SandovaliD· 1 shared Direna Alonso‐CurbeloiD· 1 shared ELVIRA M. ISGANAITISiD· 1 shared JEREMY I. CHIMENE-WEISSiD· 1 shared Jessica DesmondiD· 1 shared Joji KusuyamaiD· 1 shared

Activity by Year

2022-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperSystems Biology

Chisayo KozukaORCID

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1 paper

Recent·Most cited

Bromodomain inhibition reveals FGF15/19 as a target of epigenetic regulation and metabolic control

Chisayo Kozuka, Vissarion Efthymiou, Vicência Sales, Liyuan Zhou, Soravis Alm Osataphan, Yixing Yuchi, JEREMY I. CHIMENE-WEISS, Christopher M. Mulla, ELVIRA M. ISGANAITIS, Jessica Desmond, Suzuka Sanechika, Joji Kusuyama, Laurie J. Goodyear, Xu Shi, Robert Edgardo Gerszten, , Mary‐Elizabeth Patti

The paper shows that inhibiting bromodomain proteins like BRD4 reduces FGF15/19 expression, leading to hyperglycemia, and that overexpressing FGF19 can reverse these effects.

Diabetes · Jan 31, 2022Peer-reviewedSystems Biology