Author

Vissarion Efthymiou

Joslin Diabetes CenterORCID 0000-0003-4327-7977Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Research Focus:metabolism & bioenergetics· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Mary‐Elizabeth PattiiD· 3 shared Ashley H. VernoniD· 2 shared Yixing YuchiiD· 2 shared A. Sina BooeshaghiiD· 1 shared Aaron StreetsiD· 1 shared Adhideb GhoshiD· 1 shared Allison B. GoldfineiD· 1 shared Anish A. Konkar· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersSystems Biology

Mary‐Elizabeth PattiORCID

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4 papers

Recent·Most cited

Cell BiologyDOAJ (DOAJ: Directory of Open Access Journals)Peer-reviewedAug 5, 2026

Single-Nucleus Analysis of Human White Adipose Tissue Reveals Adipocyte Subsets with Distinct Metabolic Profiles

Vissarion Efthymiou, Adhideb Ghosh, Sean David Kodani…·Mary‐Elizabeth Patti

The paper identifies distinct adipocyte subsets in human white adipose tissue with different metabolic profiles and links TSHZ3 to their regulation and metabolic disease associations.

DOI 10.1038/s41467-026-75426-6

humanscRNA-seq

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PhysiologyDiabetes Obesity and MetabolismPeer-reviewedDec 12, 2025

Hepatic GCGR is required for the superior weight loss effects of a structurally related analogue of the dual GCGR/GLP1R agonist survodutide

Fen Long, Tenagne D. Challa, Vissarion Efthymiou…·Carla Horváth

The paper shows that hepatic GCGR is essential for the enhanced weight loss and lipid clearance effects of a dual GCGR/GLP1R agonist compared to a selective GLP1R agonist.

3 citations

humanexperimental assay

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Systems BiologyDiabetesPeer-reviewedJan 31, 2022

Bromodomain inhibition reveals FGF15/19 as a target of epigenetic regulation and metabolic control

Chisayo Kozuka, Vissarion Efthymiou, Vicência Sales…·Mary‐Elizabeth Patti

The paper shows that inhibiting bromodomain proteins like BRD4 reduces FGF15/19 expression, leading to hyperglycemia, and that overexpressing FGF19 can reverse these effects.

11 citations

mousehuman

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Systems BiologyNature CommunicationsPeer-reviewedNov 29, 2021

Novel mediation analysis of human plasma proteome and metabolome reveals mediators of improved glycemia after gastric bypass surgery

Jonathan M. Dreyfuss, Yixing Yuchi, Xuehong Dong…·Mary‐Elizabeth Patti

The paper identifies mediators of improved glycemia after gastric bypass surgery using a high-throughput mediation analysis method applied to plasma proteome and metabolome data.

34 citationstop 3%

humanproteomics

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