ImmunologyNature CommunicationsPeer-reviewed
Distinct Binding Modes of Inter-Spike Cross-Linking Suggest a Supplementary Mechanism for SARS-CoV-2 Antibody Neutralization
Xuanyu Nan, Yujie Li, Rui Zhang…·Yuhe Renee Yang
This study uses cryo-EM to show that the W328-6H2 antibody forms different structures with SARS and Omicron BA.1 spike proteins, revealing a supplementary neutralization mechanism beyond RBD-Fab binding.
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