Yujie Li

CryoGO provides a method to generate high-resolution structural data of endogenous macromolecules from cells using cryo-EM, enabling detailed structural profiling with minimal sample requirements.

This study reveals the structure and function of the cytoplasmic lattice in mammalian eggs, showing it sequesters ubiquitination machinery and tubulin for use during early embryonic development.

This paper shows that NDRG1 suppresses pancreatic cancer metastasis by disrupting exosome-mediated communication between cancer cells and the tumor microenvironment.

This study uses cryo-EM to show that the W328-6H2 antibody forms different structures with SARS and Omicron BA.1 spike proteins, revealing a supplementary neutralization mechanism beyond RBD-Fab binding.