Nihal Singh

Bioactive Spermidine-Crosslinked DNA Hydrogel for rapid homeostasis and accelerated wound healing

This paper develops a DNA hydrogel that rapidly stops bleeding and promotes tissue regeneration in mice by combining hemostasis with bioactive properties.

DNA cross-over motifs based, programmable supramolecular hydrogels for mechanoregulatory effects of cellular behaviour and cytoskeleton reorganization

This paper develops DNA-based hydrogels with tunable mechanical properties to regulate cellular behavior and cytoskeleton reorganization in RPE1 cells.

Programmable DNA-Silk fibroin hydrogel scaffold with temporal mechanical reinforcement for mesenchymal stem cells differentiation and accelerated wound healing in a full-thickness skin defect mice model

This paper develops a DNA-silk fibroin hybrid hydrogel that enhances mesenchymal stem cell differentiation and accelerates wound healing in mice.

Self-assembled DNA-collagen bioactive scaffolds promote cellular uptake and neuronal differentiation

This study develops self-assembled DNA-collagen scaffolds that enhance cellular uptake and promote neuronal differentiation of precursor cells.

Peptide modified, programmable DNA tetrahedra to modulate autophagy in biological systems

This paper introduces a DNA tetrahedron-BH3 peptide nanosystem that selectively induces autophagy by disrupting Beclin 1-Bcl2 interaction, showing reduced ROS and no apoptosis in HeLa cells and zebrafish larvae.

Programmable soft DNA hydrogels stimulate cellular endocytic pathways and proliferation

This paper develops DNA-based hydrogels that stimulate cellular endocytic pathways and proliferation by mimicking in vivo environments through programmable supramolecular structures.