BioengineeringbioRxivPreprint
Peptide modified, programmable DNA tetrahedra to modulate autophagy in biological systems
Hema Naveena A, Krupa Kansara, Nihal Singh…·Dhiraj Devidas Bhatia
This paper introduces a DNA tetrahedron-BH3 peptide nanosystem that selectively induces autophagy by disrupting Beclin 1-Bcl2 interaction, showing reduced ROS and no apoptosis in HeLa cells and zebrafish larvae.