A DNA Typewriter records the cell lineage history of a mouse, from zygote to late organogenesis
Qi Yu, Haedong Kim, Sophie Seidel, James F. Clark, Beth Martin, Kyle O'Connor, Riza M. Daza, Molly J. Gasperini, Jenny F. Nathans, Maggie Lam, Elena Gamo, Shruthi VijayKumar, Lauren M. Kuo, Jean‐Benoît Lalanne, Kamen P. Simeonov, , Jay Shendure
A prime-editing recorder in one mouse embryo yields a dated, zygote-rooted lineage tree of 1.28M cells at E13.5, enabling clonal dominance, sibling-fate and cell-type coupling analyses.
Science · Oct 8, 2026Peer-reviewedDevelopmental Biology✦ In-depth digest