GeneticsbioRxivPreprint
Targeting AKAP13 RhoGEF activity ameliorates pro-fibrotic phenotypes driven by the IPF associated AKAP13 risk variant
Bin Liu, James Michael May, Greg Contento…·Alison E. John
This study shows that an AKAP13 genetic variant promotes fibrosis by altering epithelial signaling, and inhibiting AKAP13's RhoGEF activity reduces fibrotic markers in IPF models.
DOI 10.64898/2026.01.21.700846