HIHISIV is a database that integrates and provides tools to analyze gene expression data from HIV and SIV host immune responses in humans and nonhuman primates.

BMC Bioinformatics · Mar 22, 2024Peer-reviewedBioinformatics

Transcriptional profile of ribosome-associated quality control components and their associated phenotypes in mammalian cells

Otávio Augusto L. dos Santos, Rodolfo Lopes Carneiro, Rodrigo Dias Requião, Marcelo Ribeiro Alves, Tatiana Domitrovic, Fernando Lucas Palhano

The paper examines RQC gene expression and phenotypes across human tissues, finding widespread expression and mild effects of RQC silencing, with TCF25 showing mRNA-protein discordance due to proteasomal degradation.

Scientific Reports · Jan 16, 2024Peer-reviewedBioinformatics

Congenital Zika Syndrome is associated with interferon alfa receptor 1

Tamiris Azamor, Daniela Prado Cunha, Andréa Marques Vieira da Silva, Ohanna Cavalcanti de Lima Bezerra, Marcelo Ribeiro Alves, Thyago Leal-Calvo, Fernanda S. G. Kehdy, Fernanda Saloum de Neves Manta, Thiago Gomes de Toledo-Pinto, Laís Pereira Ferreira, Elyzabeth Avvad Portari, Letícia da Cunha Guida, Leonardo Henrique Ferreira Gomes, Maria Elisabeth Lopes Moreira, Elizeu Fagundes de Carvalho, , Milton Ozório Moraes

The paper identifies a genetic variant in IFNAR1 associated with increased risk of Congenital Zika Syndrome and shows altered placental gene expression related to type I and III interferon imbalance.

Frontiers in Immunology · Nov 25, 2021Peer-reviewedGenetics

Natural variation of the cardiac transcriptome in humans

Tatiana Domitrovic, Mariana H. Moreira, Rodolfo Lopes Carneiro, Marcelo Ribeiro Alves, Fernando Lucas Palhano

The paper examines gene-expression variation in human hearts, identifying highly variable genes linked to immune response and disease phenotypes.

RNA Biology · Dec 1, 2020Peer-reviewedGenomics

Influence of Activating and Inhibitory Killer Immunoglobulin-Like Receptors (KIR) genes on the recurrence rate of ocular toxoplasmosis in Brazil

Daiana de Souza Perce-da-Silva, Thays Euzebio Joaquim, Ana Luisa Quintella do Couto Aleixo, Juliana Motta, Marcelo Ribeiro Alves, Joseli Oliveira-Ferreira, Luís Cristóvão Pôrto, Dalma Maria Banic, Maria Regina Reis Amendoeira

The paper investigates the association between KIR gene polymorphism and recurrence rates of ocular toxoplasmosis in Brazilian patients, finding protective and susceptibility markers.

bioRxiv · Sep 16, 2020 · PreprintMolecular Biology

Icosahedral viruses defined by their positively charged domains: a signature for viral identity and capsid assembly strategy

Rodrigo Dias Requião, Rodolfo Lopes Carneiro, Mariana H. Moreira, Marcelo Ribeiro Alves, Silvana Rossetto, Fernando Lucas Palhano, Tatiana Domitrovic

The paper identifies a conserved positively charged arginine-rich domain in icosahedral viruses that correlates with capsid assembly and genome packaging strategies.

Scientific Reports · Mar 25, 2020Peer-reviewedBioinformatics

Natural avirulent Shigella boydii strain in the Brazilian Amazon lacks major virulence genes and present Type II, Type III and Type VI Secretion Systems

Paula Taquita Serra, João Victor Verçosa, Ruth Moura de Souza, Paloma Inessa de Souza Dantas, Alan de Oliveira Rezende, Ana Paula Miranda Barros, Aline Rubens de Souza, Marcelo Ribeiro Alves, Marcelo de Souza Fernandes Pereira, Antônio Balieiro, Tainá Raiol, Luiz André Moraes Mariúba, Milton Ozório de Moraes, Sabrina Epiphanio, Najla Benevides Matos, , Patrícia Puccinelli Orlandi

This paper characterizes an avirulent Shigella boydii strain from Brazil, showing it lacks major virulence genes and possesses Type II, III, and VI Secretion Systems.

bioRxiv · Nov 1, 2018 · PreprintMicrobiology

GeNNet: An Integrated Platform for Unifying Scientific Workflow Management and Graph Databases for Transcriptome Data Analysis

Raquel L. Costa, Luiz M. R. Gadelha Jr., Marcelo Ribeiro Alves, Fabio Andre Machado Porto

GeNNet integrates scientific workflows with graph databases for transcriptome analysis, enabling gene selection, differential expression, and network reasoning.

PeerJ · Jul 5, 2017Peer-reviewedBioinformatics