This paper conducts a genome-wide association study of Alzheimer's disease and dementia in a multi-ancestry military cohort, identifying 72 new dementia-associated loci through meta-analysis.

medRxiv · May 7, 2026 · PreprintGenetic & Genomic Medicine

A multi-ancestry polygenic risk score for Alzheimer disease is associated with cognitive decline, hippocampal atrophy and neuropathological hallmarks in diverse populations

Nuzulul Kurniansyah, Shinya Tasaki, Habbiburr Rehman, Congcong Zhu, John J. Farrell, Richard Sherva, Richard Hauger, Victoria C. Merritt, Matthew S. Panizzon, Rui Zhang, John Michael Gaziano, Jungsoo Gim, Kun Ho Lee, Dong Yong Lee, Kwangsik T. Nho, , Lindsay A. Farrer

This paper develops an APOE-independent polygenic risk score for Alzheimer's disease that shows associations with cognitive decline and neuropathological markers across diverse populations.

medRxiv · Sep 24, 2025 · PreprintGenetic & Genomic Medicine

Mechanosensitive channel PIEZO1 enhances endometrial decidualization via BECN1-dependent autophagy

Jin-Wen Kang, Yao Wu, Yu Alex Zhang, Huixia Li, Guangya Li, Yao-Feng Yang, Xiao-Qing Huang, Jia-Ying Yu, Chen Liang, Rui Zhang, Xiao‐Zheng Liu, Shanshan Song, Yingnan Liu, Aftab Shaukat, Yong Song, , Ren‐Wei Su

This study shows that PIEZO1 enhances decidualization by promoting BECN1-dependent autophagy in response to ECM stiffness and cell contraction.

bioRxiv · Aug 5, 2025 · PreprintPhysiology

African Ancestry GWAS of Dementia in a Large Military Cohort Identifies Significant Risk Loci

Richard Sherva, Rui Zhang, Nathan J Sahelijo, Gyungah Jun, Tori R. Anglin-Foote, Catherine Chanfreau, Kelly Cho, Jennifer R. Fonda, J. Michael Gaziano, Kelly M. Harrington, Yuk-Lam Anne Ho, William S. Kremen, ELIZABETH M. LITKOWSKI, Julie Ann Lynch, Zoe E. Neale, , Mark W. Logue

This study performs a GWAS of dementia in African-ancestry individuals, identifying risk loci and highlighting differences in gene expression.

Molecular Psychiatry · Dec 21, 2022Peer-reviewedGenetic & Genomic Medicine