William S. Kremen

A Novel Method to Disentangle Tightly Linked Risk and Resilience Genes for Brain Disorders Application to Alzheimers Disease

The paper introduces an adversarial neural network to identify genetic resilience markers in Alzheimer's disease, finding five SNPs associated with resilience independent of polygenic risk scores.

Image-Based Meta- and Mega-Analysis (IBMMA): A Unified Framework for Large-Scale, Multi-Site, Neuroimaging Data Analysis

IBMMA improves neuroimaging analysis by handling missing data and large datasets, revealing new brain region findings overlooked by traditional methods.

Profiling brain morphology for autism spectrum disorder with two cross-culture large-scale consortia

This study identifies two ASD subgroups with distinct brain morphology using cross-cultural datasets, highlighting key brain regions associated with subgroup characteristics and autistic traits.

Testing the causal impact of amyloidosis on total Tau using a genetically informative sample of adult male twins.

This study examines the causal relationship between amyloid-beta biomarkers and total Tau in twins, finding no direct causal link but suggesting a causal impact on neurofilament light chain.

Genomic Structural Equation Modeling Reveals Latent Phenotypes in the Human Cortex with Distinct Genetic Architecture

The paper uses genomic structural equation modeling to identify latent genetic factors underlying cortical surface area and thickness, finding genetic correlations with psychiatric disorders.

Genetic and environmental contributions to eigengene expression

The paper estimates genetic and environmental contributions to module eigengenes (MEs) derived from blood lymphocytes in older male twins, finding significant heritability in 56% of detected MEs.

Bridging Big Data: Procedures for Combining Non-equivalent Cognitive Measures from the ENIGMA Consortium

The paper demonstrates a data harmonization process for memory testing across 53 studies, reducing inter-site variance while preserving covariate effects.

African Ancestry GWAS of Dementia in a Large Military Cohort Identifies Significant Risk Loci

This study performs a GWAS of dementia in African-ancestry individuals, identifying risk loci and highlighting differences in gene expression.

Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup

This study finds smaller total and subregional cerebellar volumes in PTSD compared to controls using a large dataset and advanced parcellation methods.

The genetic and environmental etiology of blood-based biomarkers related to the risks of Alzheimer's Disease in a population-based sample of early old age men

This study investigates the genetic and environmental factors influencing blood-based biomarkers related to Alzheimer's disease risk in middle-aged men.

Polygenic resilience scores capture protective genetic effects for Alzheimers disease

This study identifies genetic resilience factors for Alzheimer's disease by constructing polygenic resilience scores that reduce genetic risk penetrance and correlate with polygenic risk scores in unaffected individuals.

Brain charts for the human lifespan

The paper introduces brain charts as a standardized resource for benchmarking brain morphology across the human lifespan using MRI data from a large and diverse cohort.

The genetic etiology of longitudinal measures of predicted brain ageing in a population-based sample of mid to late-age males

This study investigates the genetic and environmental factors influencing longitudinal predicted brain ageing (PBA) using MRI data from mid to late-age males, finding significant genetic heritability and stability over time.

Metabolites associated with early cognitive changes implicated in Alzheimer’s disease

The paper identifies seven metabolites associated with executive function decline in early Alzheimer’s disease using longitudinal plasma samples from the WRAP cohort.

Associations between Early Midlife Lifestyle Behaviors, Young Adult Cognitive Reserve and Advanced Predicted Brain Age in Late Midlife

This study examines how early midlife lifestyle behaviors and young adult cognitive reserve influence late midlife brain aging and mild cognitive impairment.

Baseline Semantic Fluency Is Associated with Six-Year Progression to Mild Cognitive Impairment in Middle-Aged Men

The paper shows that poor episodic memory and semantic verbal fluency in middle-aged men predict progression to mild cognitive impairment within six years.

The genetic organization of subcortical volumetric change is stable throughout the lifespan

This paper identifies stable developmental clusters of subcortical volumetric change across the lifespan and shows genetic organization within these clusters.

Age-dependent genetic variants associated with longitudinal changes in brain structure across the lifespan

This study identifies genetic variants linked to longitudinal brain structure changes across the lifespan using MRI data from 15,640 individuals.

Aβ-Positivity Predicts Cognitive Decline but Cognition Also Predicts Progression to Aβ-Positivity

The paper shows that cognitive function predicts progression to Aβ-positivity, even when controlling for baseline biomarker levels, suggesting cognitive measures may identify early AD risk.

Pupillary dilation responses as a midlife indicator of risk for Alzheimer’s Disease: Association with Alzheimer’s disease polygenic risk

The paper shows that higher Alzheimer’s disease polygenic risk scores are linked to greater pupillary dilation during cognitive tasks in midlife, suggesting a genetic biomarker for early AD risk.

Hippocampal subfield volumes are uniquely affected in PTSD and depression: International analysis of 31 cohorts from the PGC-ENIGMA PTSD Working Group

This study identifies hippocampal subfield volume differences in PTSD and depression across 31 cohorts, finding depression has a stronger effect than PTSD, especially in CA1, with comorbid cases showing more pronounced changes.

Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities

This study identifies genetic loci specific to periventricular and deep white matter hyperintensities, revealing distinct genetic architectures and potential biological mechanisms.

Altered White Matter Microstructural Organization in Post-Traumatic Stress Disorder across 3,049 Adults: Results from the PGC-ENIGMA PTSD Consortium

This study identifies reduced fractional anisotropy in the tapetum region of the corpus callosum in PTSD patients using a large multi-cohort analysis of diffusion MRI data.

Genetic risk for coronary heart disease alters the influence of Alzheimer’s genetic risk on mild cognitive impairment

The paper examines how genetic risk for coronary heart disease interacts with Alzheimer’s genetic risk to influence mild cognitive impairment risk in a cohort of 1,209 individuals.

Planar cell polarity pathway and development of the human visual cortex

The paper identifies genetic associations with cortical surface area using PCA and GWAS, linking DAAM1 to visual cortex development through mitochondrial pathways and thalamocortical input.

Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

This study conducts the largest GWAS for PTSD, identifying 6 genome-wide significant loci in European and African ancestries and highlighting novel biological pathways.

Brain structure mediates the association between height and cognitive ability

The paper investigates whether cortical size mediates the association between height and cognitive ability using twin data.

PTSD Blood Transcriptome Mega-Analysis: Shared Inflammatory Pathways Across Biological Sex And Modes Of Trauma

This study identifies shared and sex-specific inflammatory pathways in PTSD through a meta-analysis of blood transcriptomes across different trauma types and biological sexes.