Matthew S. Panizzon

A Genome-wide Association Study of Alzheimer's Disease and Dementia in a Large Multi-ancestry Military Cohort Identifies Many New Dementia-Associated Loci

This paper conducts a genome-wide association study of Alzheimer's disease and dementia in a multi-ancestry military cohort, identifying 72 new dementia-associated loci through meta-analysis.

Evaluating a Genome-Wide Polygenic Score for Handgrip Strength and Its Interplay with Leisure-Time Physical Activity Across the IGEMS Twin Cohorts

The paper evaluates a polygenic score for handgrip strength and its interaction with physical activity across twin cohorts, finding a significant genetic association and effect modification by physical activity.

Neurobiological Signatures of Endometriosis: Characterizing Pain, Cognition, and Brain Morphology

This study investigates the neurobiological correlates of endometriosis by integrating neuroimaging, biofluids, and cognitive assessments, finding pain-related brain structure and microstructure changes in affected individuals.

Image-Based Meta- and Mega-Analysis (IBMMA): A Unified Framework for Large-Scale, Multi-Site, Neuroimaging Data Analysis

IBMMA improves neuroimaging analysis by handling missing data and large datasets, revealing new brain region findings overlooked by traditional methods.

Genomic analyses reveal new insights into Alzheimer's disease

This study identifies 118 new genetic loci associated with Alzheimer's disease across diverse ancestries and discovers 48 novel risk loci, including those enriched in neuronal cell types.

A multi-ancestry polygenic risk score for Alzheimer disease is associated with cognitive decline, hippocampal atrophy and neuropathological hallmarks in diverse populations

This paper develops an APOE-independent polygenic risk score for Alzheimer's disease that shows associations with cognitive decline and neuropathological markers across diverse populations.

Prevalence and disease risks for male and female sex chromosome trisomies: a registry-based phenome-wide association study in 1.5 million participants of MVP, FinnGen, and UK Biobank

This study identifies prevalence and disease risks for male and female sex chromosome trisomies using registry data from 1.5 million participants, finding shared phenotypic associations across trisomy subtypes.

Testing the causal impact of amyloidosis on total Tau using a genetically informative sample of adult male twins.

This study examines the causal relationship between amyloid-beta biomarkers and total Tau in twins, finding no direct causal link but suggesting a causal impact on neurofilament light chain.

Genomic Structural Equation Modeling Reveals Latent Phenotypes in the Human Cortex with Distinct Genetic Architecture

The paper uses genomic structural equation modeling to identify latent genetic factors underlying cortical surface area and thickness, finding genetic correlations with psychiatric disorders.

Genome-wide Association Study of Traumatic Brain Injury in U.S. Military Veterans Enrolled in the VA Million Veteran Program

This study conducts a genome-wide association study (GWAS) of traumatic brain injury (TBI) in U.S. military veterans, identifying 15 genome-wide significant loci and showing genetic correlations with psychiatric traits.

Prevalence, Morbidity, and Mortality of 1,609 Men with Diagnosed and Undiagnosed Sex Chromosome Aneuploidy: Results from the Diverse Million Veteran Program (MVP) Cohort

The paper examines the prevalence, morbidity, and mortality of sex chromosome aneuploidy in men from the MVP cohort, finding a prevalence of 1 in 370 males with higher healthcare utilization and poorer HRQoL but similar life expectancy compared to controls.

African Ancestry GWAS of Dementia in a Large Military Cohort Identifies Significant Risk Loci

This study performs a GWAS of dementia in African-ancestry individuals, identifying risk loci and highlighting differences in gene expression.

The genetic and environmental etiology of blood-based biomarkers related to the risks of Alzheimer's Disease in a population-based sample of early old age men

This study investigates the genetic and environmental factors influencing blood-based biomarkers related to Alzheimer's disease risk in middle-aged men.

Sex differences in migraine: A twin study

This study investigates sex differences in migraine prevalence using twin data, finding that genetic factors alone do not fully explain the sex difference, but prenatal hormone environments may contribute.

The genetic etiology of longitudinal measures of predicted brain ageing in a population-based sample of mid to late-age males

This study investigates the genetic and environmental factors influencing longitudinal predicted brain ageing (PBA) using MRI data from mid to late-age males, finding significant genetic heritability and stability over time.

Associations between Early Midlife Lifestyle Behaviors, Young Adult Cognitive Reserve and Advanced Predicted Brain Age in Late Midlife

This study examines how early midlife lifestyle behaviors and young adult cognitive reserve influence late midlife brain aging and mild cognitive impairment.

Baseline Semantic Fluency Is Associated with Six-Year Progression to Mild Cognitive Impairment in Middle-Aged Men

The paper shows that poor episodic memory and semantic verbal fluency in middle-aged men predict progression to mild cognitive impairment within six years.

The genetic organization of subcortical volumetric change is stable throughout the lifespan

This paper identifies stable developmental clusters of subcortical volumetric change across the lifespan and shows genetic organization within these clusters.

Age-dependent genetic variants associated with longitudinal changes in brain structure across the lifespan

This study identifies genetic variants linked to longitudinal brain structure changes across the lifespan using MRI data from 15,640 individuals.

Aβ-Positivity Predicts Cognitive Decline but Cognition Also Predicts Progression to Aβ-Positivity

The paper shows that cognitive function predicts progression to Aβ-positivity, even when controlling for baseline biomarker levels, suggesting cognitive measures may identify early AD risk.

Pupillary dilation responses as a midlife indicator of risk for Alzheimer’s Disease: Association with Alzheimer’s disease polygenic risk

The paper shows that higher Alzheimer’s disease polygenic risk scores are linked to greater pupillary dilation during cognitive tasks in midlife, suggesting a genetic biomarker for early AD risk.

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

The paper identifies 161 genome-wide significant genetic associations for cortical structure traits across 34 brain regions, highlighting key biological pathways and gene functions.

Genetic risk for coronary heart disease alters the influence of Alzheimer’s genetic risk on mild cognitive impairment

The paper examines how genetic risk for coronary heart disease interacts with Alzheimer’s genetic risk to influence mild cognitive impairment risk in a cohort of 1,209 individuals.

Brain structure mediates the association between height and cognitive ability

The paper investigates whether cortical size mediates the association between height and cognitive ability using twin data.