Mark W. Logue

This paper conducts a genome-wide association study of Alzheimer's disease and dementia in a multi-ancestry military cohort, identifying 72 new dementia-associated loci through meta-analysis.

This paper develops an APOE-independent polygenic risk score for Alzheimer's disease that shows associations with cognitive decline and neuropathological markers across diverse populations.

This study identifies differentially expressed genes and pathways in Alzheimer's disease brain tissue from African American donors, highlighting potential targets for treatment.

The paper uses genomic structural equation modeling to identify latent genetic factors underlying cortical surface area and thickness, finding genetic correlations with psychiatric disorders.

This study conducts a genome-wide association study (GWAS) of traumatic brain injury (TBI) in U.S. military veterans, identifying 15 genome-wide significant loci and showing genetic correlations with psychiatric traits.

This study performs a GWAS of dementia in African-ancestry individuals, identifying risk loci and highlighting differences in gene expression.

This paper compares four methods for harmonizing cortical thickness data across multiple sites and finds that ComBat-GAM is most effective in detecting case-control differences and age-related cortical thinning.

This study investigates the genetic and environmental factors influencing longitudinal predicted brain ageing (PBA) using MRI data from mid to late-age males, finding significant genetic heritability and stability over time.

This study examines structural covariance networks in PTSD using a large multisite dataset, finding differences in centrality measures between PTSD and control groups, and highlighting sex-based and comorbid differences.

CUE imputes DNA methylation from HM450 to HM850 platforms, achieving lower RMSE and higher accuracy than existing methods across two cohorts.

The paper shows that higher Alzheimer’s disease polygenic risk scores are linked to greater pupillary dilation during cognitive tasks in midlife, suggesting a genetic biomarker for early AD risk.

This study identifies genetic loci specific to periventricular and deep white matter hyperintensities, revealing distinct genetic architectures and potential biological mechanisms.

This study identifies reduced fractional anisotropy in the tapetum region of the corpus callosum in PTSD patients using a large multi-cohort analysis of diffusion MRI data.

The paper identifies 161 genome-wide significant genetic associations for cortical structure traits across 34 brain regions, highlighting key biological pathways and gene functions.

The paper examines how genetic risk for coronary heart disease interacts with Alzheimer’s genetic risk to influence mild cognitive impairment risk in a cohort of 1,209 individuals.

This study identifies ten novel methylation loci associated with PTSD through a meta-analysis of 1,896 cases and controls across ten cohorts, highlighting the AHRR locus and its link to kynurenine levels.

The paper identifies SNRNP35 as a trauma type-specific PTSD gene through analysis of genetically regulated gene expression in PTSD cases and controls.

This study uses genetic data to show that educational attainment causally reduces PTSD risk, with economic status mediating this relationship.

This study conducts the largest GWAS for PTSD, identifying 6 genome-wide significant loci in European and African ancestries and highlighting novel biological pathways.