This study identifies gene-diet interactions that influence cognitive resilience to Alzheimer's disease in mice, finding a diet-dependent genetic locus associated with resilience.

bioRxiv · Feb 7, 2025 · PreprintNeuroscience

Proteomic Networks and Related Genetic Variants Associated with Smoking and Chronic Obstructive Pulmonary Disease

Iain R. Konigsberg, Thao Vu, W. M. Liu, ELIZABETH M. LITKOWSKI, Katherine Pratte, Luciana B. Vargas, Niles Gilmore, Mohamed Abdel-Hafiz, Ani W Manichaikul, Michael H. Cho, Craig P. Hersh, Dawn Lisa DeMeo, Farnoush Banaei‐Kashani, Russell Paul Bowler, Leslie A. Lange, Katerina J. Kechris

The paper identifies proteomic networks and genetic variants associated with smoking and COPD phenotypes using multi-ethnic proteomic data and network-based GWAS.

BMC Genomics · Sep 2, 2024Peer-reviewedGenetic & Genomic Medicine

Hippocampus Glutathione S Reductase Potentially Confers Genetic Resilience to Cognitive Decline in the AD-BXD Mouse Population

Michael C. Saul, ELIZABETH M. LITKOWSKI, Niran Hadad, Amy R. Dunn, Stephanie M. Boas, Jon A. L. Willcox, Julia E. Robbins, Yiyang Wu, Vivek M. Philip, Gennifer E. Merrihew, Jea Park, Philip L. De Jager, Dave Bridges, Vilas Menon, David Alan Bennett, , Catherine Cook Kaczorowski

The paper identifies a genetic locus and protein associated with resilience to cognitive decline in AD-BXD mice and links it to human AD traits.

bioRxiv · Jan 9, 2024 · PreprintNeuroscience

African Ancestry GWAS of Dementia in a Large Military Cohort Identifies Significant Risk Loci

Richard Sherva, Rui Zhang, Nathan J Sahelijo, Gyungah Jun, Tori R. Anglin-Foote, Catherine Chanfreau, Kelly Cho, Jennifer R. Fonda, J. Michael Gaziano, Kelly M. Harrington, Yuk-Lam Anne Ho, William S. Kremen, ELIZABETH M. LITKOWSKI, Julie Ann Lynch, Zoe E. Neale, , Mark W. Logue

This study performs a GWAS of dementia in African-ancestry individuals, identifying risk loci and highlighting differences in gene expression.

Molecular Psychiatry · Dec 21, 2022Peer-reviewedGenetic & Genomic Medicine

Proteomic Fingerprinting: A novel privacy concern

Andrew C. Hill, ELIZABETH M. LITKOWSKI, Ani W Manichaikul, Leslie A. Lange, Katherine Pratte, Katerina J. Kechris, Matthew W. DeCamp, Marilyn E. Coors, Victor E. Ortega, Stephen S. Rich, Jerome I. Rotter, Robert Edgardo Gerszten, Clary B. Clish, Jeffrey L. Curtis, Xiaowei Hu, , Russell Paul Bowler

This study shows that proteomic data can be linked to specific genomes using pQTL knowledge, highlighting privacy risks and the need for protections similar to genomic data.

medRxiv · Apr 6, 2022 · PreprintGenetic & Genomic Medicine