A chimeric viral platform for directed evolution in mammalian cells
Alexander J. Cole, Christopher E. Denes, Cesar L. Moreno, Lise Hunault, Thomas Dobson, Daniel Hesselson, G. Gregory Neely
This paper introduces PROTEUS, a chimeric viral platform for directed evolution in mammalian cells, demonstrating its ability to generate sensitive gene regulation tools and DNA damage-responsive nanobodies.
Nature Communications · May 7, 2025Peer-reviewedMolecular Biology