Synthetic BiologybioRxivPreprint
"Cheater" particles render the VEGAS platform unsuitable for mammalian directedevolution
Christopher E. Denes, Alexander J. Cole, Minh Thuan Nguyen Tran…·G. Gregory Neely
The paper shows the VEGAS platform for mammalian directed evolution is ineffective due to cheater particles that outcompete transgenes and prevent directed evolution.
DOI 10.1101/2022.06.07.495067