G. Gregory Neely

The paper describes a low-cost, lab-assembled TFF system for EV isolation from diverse cell culture sources and evaluates its performance with and without SEC.

The paper shows how SARS-CoV-2 variants, particularly Omicron, evolved proteolytic controls at the Spike furin cleavage site to enhance transmission while reducing lower respiratory tract pathogenicity.

The paper identifies FBXW11 as a negative regulator of radial glial expansion and neuronal maturation in human cerebral organoids through CRISPR screening and functional validation.

This study presents a multi-omic atlas of the siphonophore Physalia utriculus, revealing the regulatory mechanisms of colonial division of labour and the molecular basis of venom activity.

This study shows that Drosophila prickle mutants exhibit ASD-like behaviors and neurological anomalies, linking PRICKLE function to both epilepsy and autism spectrum disorder.

This study shows that enkephalin released in the amygdala during fear learning suppresses dopamine release, thereby constraining fear memory formation.

The paper demonstrates that intranasal delivery of BDNF mRNA improves memory in aged and Alzheimer's mouse models.

This study demonstrates that intranasal mRNA-LNP delivery of synthetic oxytocin promotes social behavior and reduces pain without systemic inflammation or motor impairment.

This study identifies PRDM9 as a factor promoting survival of drug-tolerant persister cells in glioblastoma through metabolic rewiring and cholesterol biosynthesis.

This study identifies SEC61B as a regulator of calcium flux and platelet hyperreactivity in diabetes by linking ER stress to increased SEC61B expression and calcium leak.

This paper shows that SARS-CoV-2 Omicron lineages replicate using a specific ACE2 pool that does not complex with TMPRSS2, unlike pre-Omicron variants.

The paper identifies differences in stress response and function between macular and peripheral Muller cells, linking these differences to vulnerability to degenerative diseases.

This paper introduces PROTEUS, a chimeric viral platform for directed evolution in mammalian cells, demonstrating its ability to generate sensitive gene regulation tools and DNA damage-responsive nanobodies.

This study differentiates and characterizes iPSC-derived astrocytes and microglia from PSEN2 (N141I) mutation carriers, showing a primed inflammatory phenotype with altered cytokine secretion and Aβ42 handling.

The paper characterizes cell-cell communication patterns in COVID-19 patients to identify differences between moderate and severe disease outcomes using single-cell RNA-seq data.

The paper shows the VEGAS platform for mammalian directed evolution is ineffective due to cheater particles that outcompete transgenes and prevent directed evolution.

This study shows TM2D genes regulate Notch signaling and neuronal function in Drosophila, with implications for Alzheimer's disease.