Central T3 deprivation disturbs cortical cilia formation, oligodendrocyte lineage and neuronal cell-cell-communication in a MCT8/OATP1C1 deficient Allan-Herndon-Dudley Syndrome mouse model
Anna Molenaar, Ekta Pathak, Miriam Bernecker, Noémi Mallet, Ruth Gutiérrez‐Aguilar, Cristina Mencias Castillejo, Dominik Lutter, Meri De Angelis, Gandhari Maity‐Kumar, Peter Kuehnen, Benedikt Obermayer, Robert Opitz, Sonja Charlotte Schriever, Timo D. Müller, Paul T. Pfluger
This study uses single nucleus RNA sequencing to analyze cortical and striatal development in a mouse model of Allan-Herndon-Dudley Syndrome, identifying disruptions in oligodendrocyte lineage, cell-cell communication, and cilia formation.
bioRxiv · Dec 25, 2025 · PreprintNeuroscience