Timo D. Müller

Midbrain Tet1 dosage defines inter-individual binge-eating susceptibility

This study shows that Tet1 dosage in midbrain neurons determines binge-eating susceptibility in mice and links Tet1 methylation to human binge-eating behavior.

Ectopic, hepatic GLP-1R agonism enhances the weight loss efficacy of GLP-1 analogues.

The paper shows that combining GLP-1R agonists with ectopic hepatic GLP-1R expression enhances weight loss in mice by increasing energy expenditure and reducing food intake.

Central T3 deprivation disturbs cortical cilia formation, oligodendrocyte lineage and neuronal cell-cell-communication in a MCT8/OATP1C1 deficient Allan-Herndon-Dudley Syndrome mouse model

This study uses single nucleus RNA sequencing to analyze cortical and striatal development in a mouse model of Allan-Herndon-Dudley Syndrome, identifying disruptions in oligodendrocyte lineage, cell-cell communication, and cilia formation.

Maternal Thyroid Supplementation Prevents Autistic-relevant Social Behavior and Hypothalamic Oxytocin Depletion Produced by Developmental Exposure to Environmental Toxicants

This study shows maternal thyroid supplementation prevents PBDE-induced social behavior deficits and hypothalamic oxytocin depletion in mice.

A Spatiotemporal Proteomic Map of Human Adipogenesis

This study creates a spatiotemporal proteomic map of human adipogenesis, revealing changes in protein abundance, localization, and metabolic pathway reprogramming during adipocyte differentiation.

Gene therapy targeting the blood-brain barrier improves neurological symptoms in a model of genetic MCT8 deficiency

This study demonstrates that gene therapy targeting brain endothelial cells improves neurological symptoms in a mouse model of MCT8 deficiency by increasing brain T3 levels and motor function.

Coupling of oxytocin and cholecystokinin pathways in the hypothalamus is required for gut-to-brain homeostatic feeding control

This study shows that oxytocin and cholecystokinin pathways in hypothalamic neurons are critical for gut-to-brain feeding control, with their disruption leading to hyperphagic obesity.

Hypercaloric diet triggers transient molecular rearrangements of astrocytes selectively in the arcuate nucleus

This study shows that a hypercaloric diet causes temporary molecular changes in astrocytes specifically in the arcuate nucleus of the hypothalamus.

Correlation guided Network Integration (CoNI) reveals novel genetic regulators of hepatic metabolism

CoNI integrates multi-omics data to identify genetic regulators of hepatic metabolism, validating several candidates in human liver cells and biopsies.