Ekta Pathak

EML4-ALK Fusion Rewires Transcriptomic, miRNA, and CAF-Associated Programs in Non-Small Cell Lung Cancer

This paper identifies transcriptomic, miRNA, and CAF-associated reprogramming in EML4-ALK fusion-positive NSCLC compared to fusion-negative tumors.

Fusion-driven post-transcriptional network orchestrates ferroptosis resistance, dormancy, and immune remodeling in PRCC-TFE3 renal cell carcinoma

This study identifies a fusion-driven post-transcriptional network in PRCC-TFE3 tumors that regulates ferroptosis resistance, dormancy, and immune remodeling through miRNA-mRNA interactions.

Central T3 deprivation disturbs cortical cilia formation, oligodendrocyte lineage and neuronal cell-cell-communication in a MCT8/OATP1C1 deficient Allan-Herndon-Dudley Syndrome mouse model

This study uses single nucleus RNA sequencing to analyze cortical and striatal development in a mouse model of Allan-Herndon-Dudley Syndrome, identifying disruptions in oligodendrocyte lineage, cell-cell communication, and cilia formation.

A Pan-Cancer Blueprint of Early Tumor Microenvironment Reprogramming

The paper integrates multi-omics data from 14 cancers to reveal early metabolic and transcriptional reprogramming in the tumor microenvironment, identifying key genes and pathways involved.

Integrative Transcriptomic and miRNA Analysis Reveals Immune Suppression and Metabolic Reprogramming in FGFR3-TACC3 Fusion-Positive versus Fusion-Negative Bladder Cancer

This study identifies immune suppression and metabolic reprogramming in FGFR3-TACC3 fusion-positive bladder cancer through transcriptomic and miRNA analysis, revealing fusion-specific regulatory interactions and potential therapeutic targets.

Endogenous pancreatic microRNAs differentially target the Delta, Omicron, and Wuhan SARS-CoV-2 genomes to upregulate the Diabetes-associated genes

The paper investigates how endogenous pancreatic microRNAs differentially target SARS-CoV-2 variants (Delta, Omicron, Wuhan) and upregulate diabetes-associated genes despite UTR mutations.

Linking Diabetes mellitus to SARS-CoV-2 infection through differential targeting of the microRNAs in the Pancreas tissue

The paper identifies five diabetes-associated genes upregulated in SARS-CoV-2-infected pancreatic tissue and hypothesizes that miRNA competition between viral and host genes contributes to diabetes exacerbation in COVID-19.

Deciphering the role of the Pancreatic Secretome in Covid-19 associated Multi-Organ Dysfunctions

The paper investigates the role of the SARS-CoV-2 infected pancreas secretome in multi-organ dysfunctions using scRNA-seq and identifies upregulated genes and secretory proteins linked to various organ systems and diseases.