Robert Opitz

The paper quantifies how single nucleotide variants affect NKX2.1 transcription factor binding and uses neural networks to predict disease-causing variants in regulatory regions.

This study uses single nucleus RNA sequencing to analyze cortical and striatal development in a mouse model of Allan-Herndon-Dudley Syndrome, identifying disruptions in oligodendrocyte lineage, cell-cell communication, and cilia formation.

The paper uses RNA-sequencing to show that THRA2 is predominantly expressed in human brain development and adult central nervous system tissues.

The paper characterizes the spatiotemporal expression of MCT8 and THRA in human cerebral organoids, showing their expression patterns align with early cortical development and response to thyroid hormone treatment.

This study identifies the role of FGF and BMP signaling in thyroid progenitor specification in zebrafish embryos, showing FGF regulates Pax2a and BMP regulates both Pax2a and Nkx2.4b.

This study shows that enhanced Wnt signaling during zebrafish development disrupts cardiac mesoderm-endoderm interactions, leading to thyroid specification defects and cardiovascular abnormalities.

The paper identifies BMP and FGF signaling as key regulators of thyroid development in zebrafish embryos through small molecule screening and links these findings to conserved vertebrate mechanisms.