Paul T. Pfluger

This study uses single nucleus RNA sequencing to analyze cortical and striatal development in a mouse model of Allan-Herndon-Dudley Syndrome, identifying disruptions in oligodendrocyte lineage, cell-cell communication, and cilia formation.

EasyAb is a high-throughput workflow for antibody-based PTM peptide enrichment coupled to mass spectrometry, enhancing sensitivity for large-scale PTM analysis in diverse cell systems.

The paper identifies miR-182-5p as a key microRNA linking type 2 diabetes and fatty liver disease through its regulation of LRP6 in human and mouse liver samples.

This study shows that oxytocin and cholecystokinin pathways in hypothalamic neurons are critical for gut-to-brain feeding control, with their disruption leading to hyperphagic obesity.

This study examines how pharmacologically induced weight loss in obese rats affects their gut microbiome, identifying specific microbial taxa and pathways associated with weight loss.

CoNI integrates multi-omics data to identify genetic regulators of hepatic metabolism, validating several candidates in human liver cells and biopsies.