An injectable soft implant for long-acting, reversible, ultra-stable release of therapeutics
Ceren Kütahya, Luca Panariello, Adrian Najer, Tatiana Rizou, André Shamsabadi, Giulia Brachi, David J. Peeler, Lukeriya Zharova, Thomas F. F. Fernandez Debets, Patrick Peschke, Anna P. Constantinou, Ruoxiao Xie, Yuxi Cheng, Ross Burdis, Alejandro Suárez‐Bonnet, , Molly M. Stevens
This paper develops an injectable hydrogel platform with poly(orthoester) microparticles for long-term, zero-order drug release, demonstrating in vitro and in vivo efficacy for up to 12 months.
bioRxiv · Feb 26, 2026 · PreprintBioengineering