John S. Tregoning

Spatiotemporal control of STING activation and saRNA delivery decouples humoral and cellular immunity

This study shows that timing and location of STING activation relative to saRNA delivery affects humoral and cellular immune responses, with synchronized delivery enhancing T cell responses without impacting antibody production.

A rhinovirus vaccine evokes T cell mediated cross-reactive immunity in a preclinical model of rhinovirus infection

This study evaluates a rhinovirus (RV) vaccine, showing it induces cross-reactive T cell immunity and protection against heterotypic RV infection in mice.

Le click c'est chic: a plug-and-play virus-like particle vaccination platform enabled by non-canonical amino acid incorporation and click chemistry in the tobacco BY-2 cell-free protein synthesis system

This paper introduces a method to incorporate non-canonical amino acids into proteins using the tobacco BY-2 cell-free system, enabling click chemistry for vaccine development.

Nanoscale biodegradable printing for designed tuneability of vaccine delivery kinetics

This paper develops a 3D printing method to create tunable drug delivery systems that control vaccine-induced antibody responses.