Metabolic reprogramming in the spinal cord drives the transition to pain chronicity
Alex Mabou Tagne, Yannick Fotio, Hye-Lim Lee, Kwang‐Mook Jung, Jean Katz, Faizy Ahmed, Johnny Le, Richard Paul Bazinet, Cholsoon Jang, Daniele Piomelli
The paper shows that metabolic reprogramming in the spinal cord, driven by injury, leads to chronic pain by suppressing autophagy and nutrient availability, and that dietary intervention can prevent this transition.
Cell Reports · Sep 1, 2025Peer-reviewedNeuroscience