Richard Paul Bazinet

A comprehensive characterization of the phospholipid and cholesterol composition of the uncinate fasciculus in the human brain: evidence of age-related alterations

This study characterizes the lipid composition of the human uncinate fasciculus and finds age-related changes but no significant differences related to depression or childhood abuse.

A multimodal characterization of the human uncinate fasciculus

This study characterizes the human uncinate fasciculus using multimodal approaches, finding no group differences in histology but identifying differentially expressed genes and age-related changes.

Standardized brain and plasma EV enrichment pipeline validated for Single sample multi-Omic and fatty acids applications in Mouse and Human

The paper presents a standardized workflow for multi-omic profiling of brain and plasma-derived EVs from minimal human and mouse material, revealing tissue-specific and species-specific molecular signatures.

Maternal n-3 PUFA deficiency alters brain fatty acid and oxylipin profiles across perinatal development in offspring

Metabolic reprogramming in the spinal cord drives the transition to pain chronicity

The paper shows that metabolic reprogramming in the spinal cord, driven by injury, leads to chronic pain by suppressing autophagy and nutrient availability, and that dietary intervention can prevent this transition.

Fatty acid dysregulation in the anterior cingulate cortex of depressed suicides with a history of child abuse

This study compares fatty acid concentrations in the anterior cingulate cortex of depressed suicides with and without a history of child abuse, finding age-related decreases and specific effects of child abuse on arachidonic acid synthesis pathway FAs.

Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the developing brain

Low maternal omega-3 fatty acid intake impairs microglia-mediated synaptic refinement via the 12-HETE pathway in the developing brain.