Johnny Le

This paper shows that spinal cord oligodendrocyte metabolic changes after injury lead to β-amyloid production and chronic pain.

The paper shows that metabolic reprogramming in the spinal cord, driven by injury, leads to chronic pain by suppressing autophagy and nutrient availability, and that dietary intervention can prevent this transition.

This study shows that blocking intestinal fructose catabolism reduces obesity and insulin resistance by decreasing fat absorption and altering gut microbiome and immune interactions.

This study shows diet-induced thermogenesis reduces adiposity and protects against liver disease in male mice, with UCP1 playing a key role in BAT and non-adipocyte cells.

This study identifies sex-dependent metabolic differences in kidneys using arteriovenous metabolomics and transcriptomics, revealing distinct metabolic responses to a ketogenic diet.