Author

Daniele Piomelli

University of California, IrvineORCID 0000-0002-2983-774XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 1 Assay:electronic health records· 1 Organism:human· 1 Assay:metabolomics· 1

Frequent Co-Authors

Alex Mabou TagneiD· 3 shared Cholsoon JangiD· 2 shared Johnny LeiD· 2 shared Yannick FotioiD· 2 shared Alberto GranzottoiD· 1 shared Aliza A. LeiD· 1 shared Anna Floor StevensiD· 1 shared Annamaria CiminiiD· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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3 shared papersNeuroscience

Alex Mabou TagneORCID

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5 papers

Recent·Most cited

Glycosylation of anandamide and other bioactive N-acylethanolamines in mammalian cells and tissues

Anna Floor Stevens, Remco E.A. Peter, Berend Gagestein, Maria J. Ferraz, Eline Been, Tijn Vleeshouwer, Iakovia Ttofi, Richard J. B. H. N. van den Berg, Tom van der Wel, Laura V. de Paus, Christian Deuschle, Cas van der Horst, Laura H. Heitman, Marta Artola, Daniele Piomelli, , Mario van der Stelt

The paper identifies NAE glycosylation as a metabolic pathway that links endocannabinoid metabolism to lysosomal dysfunction and inflammation.

bioRxiv · Jul 21, 2026 · PreprintBiochemistry

Metabolic reallocation in spinal cord oligodendrocytes drives chronic pain via neuronal β-amyloid production

Yannick Fotio, Saeed Al Masri, Zechuan Shi, Johnny Le, Sudeshna Das, Varvara I. Rubtsova, Alex Mabou Tagne, Cholsoon Jang, Vivek Swarup, Daniele Piomelli

This paper shows that spinal cord oligodendrocyte metabolic changes after injury lead to β-amyloid production and chronic pain.

Journal of Pain · Mar 1, 2026Peer-reviewedNeuroscience

Metabolic reprogramming in the spinal cord drives the transition to pain chronicity

Alex Mabou Tagne, Yannick Fotio, Hye-Lim Lee, Kwang‐Mook Jung, Jean Katz, Faizy Ahmed, Johnny Le, Richard Paul Bazinet, Cholsoon Jang, Daniele Piomelli

The paper shows that metabolic reprogramming in the spinal cord, driven by injury, leads to chronic pain by suppressing autophagy and nutrient availability, and that dietary intervention can prevent this transition.

Cell Reports · Sep 1, 2025Peer-reviewedNeuroscience

Microglia Depletion Selectively Eliminates a Singular Form of Hippocampal Long Term Potentiation

Jasmine Chavez, Aliza A. Le, Julian Quintanilla, Alex Mabou Tagne, Daniele Piomelli, GARY S. LYNCH, Christine M. Gall

The paper shows that microglia depletion selectively impairs a specific form of hippocampal long-term potentiation (LTP) in the lateral perforant path.

bioRxiv · Jul 29, 2022 · PreprintNeuroscience

Inhibition of de novo ceramide biosynthesis affects aging phenotype in an in vitro model of neuronal senescence

Alberto Granzotto, Manuela Bomba, Vanessa Castelli, Riccardo Navarra, Noemi Massetti, Marco D’Aurora, MARCO C. ONOFRJ, Ilaria Cicalini, Piero Del Boccio, Valentina Gatta, Annamaria Cimini, Daniele Piomelli, Stefano Luca Sensi

This study shows that inhibiting de novo ceramide biosynthesis with L-cycloserine improves aging-related phenotypes in cultured cortical neurons.

Aging · Aug 29, 2019Peer-reviewedNeuroscience