Frederic D. Sigoillot

The paper introduces a scalable platform for screening combinatorial small-molecule libraries in droplets, demonstrating its effectiveness in discovering chemical inducers of proximity and supporting machine learning-based drug design.

The paper introduces two novel readthrough promoters that induce eRF1 degradation, leading to PTC suppression and revealing a new ribosome quality control mechanism.

DRUG-seq provides high-throughput, unbiased transcriptomic data for drug discovery, demonstrating reproducibility and mechanism-of-action resolution for diverse compounds.