Lukas‐Adrian Gurzeler

The paper identifies USP9X as a deubiquitinase that regulates the degradation of trapped translation factors on stalled ribosomes, showing its role in trimming K6-linked ubiquitin chains and modulating translation feedback mechanisms.

This paper develops a 3D cell culture model using fibronectin-silk matrices to study endometriosis fibrosis and tests pirfenidone as a repurposed antifibrotic drug candidate.

The paper introduces two novel readthrough promoters that induce eRF1 degradation, leading to PTC suppression and revealing a new ribosome quality control mechanism.

This paper introduces a dual centrifugation method to produce human translation-competent lysates, enabling efficient mRNA translation in both cap-dependent and IRES-mediated ways.

This study shows SARS-CoV-2 Nsp1 binds to the 40S ribosomal subunit to inhibit translation by blocking mRNA entry, while viral mRNA enhances its own translation.

This study challenges the prevailing model of NMD by showing that ribosome stalling at stop codons does not occur during NMD activation in vitro or in vivo.