An experimental target-based platform in yeast for screening Plasmodium vivax deoxyhypusine synthase inhibitors
Suélen Fernandes Silva, Angélica Hollunder Klippel, Sunniva Sigurdardóttir, Sayyed Jalil Mahdizadeh, Ievgeniia Tiukova, Catarina Bourgard, Heloísa Monteiro do Amaral Prado, Renan Vinícius de Araújo, Elizabeth Bilsland, Ross D. King, Katlin B. Massirer, Leif Axel Eriksson, Mário Henrique Bengtson, Per Sunnerhagen, Cleslei Fernando Zanelli
The paper develops a yeast-based platform to identify Plasmodium vivax DHS inhibitors, finding two compounds that selectively inhibit parasite DHS over human DHS.
bioRxiv · Nov 23, 2023 · PreprintSynthetic Biology