Nikolaus R. McFarland

The paper uses single-cell multiomics to identify shared and unique immune dysfunction features in Parkinson's disease and inflammatory bowel disease across gut, plasma, and stool samples.

The paper stratifies Parkinson's disease stages based on peripheral immune cell responses to stimulation, identifying biomarkers linked to disease progression.

The paper investigates the role of MHCII reduction in protecting mice from alpha-synuclein-induced degeneration and finds that it is insufficient, while showing epigenetic regulation of the Parkinson's HLA locus.

The paper compares gut microbiomes of Parkinson's disease and inflammatory bowel disease patients, finding shared depletions in butyrate-producing bacteria across multiple datasets.

The paper investigates shared iron storage and transport deficits in PBMCs from PD and IBD patients, linking them to immune dysfunction and NSAID modulation.