Kelly B. Menees

This study investigates how RGS10 modulates NFκB subunit transcription and inflammatory cytokine profiles in peritoneal macrophages through experimental stimulation and transcript analysis.

The paper uses single-cell multiomics to identify shared and unique immune dysfunction features in Parkinson's disease and inflammatory bowel disease across gut, plasma, and stool samples.

The paper investigates the role of MHCII reduction in protecting mice from alpha-synuclein-induced degeneration and finds that it is insufficient, while showing epigenetic regulation of the Parkinson's HLA locus.

The paper investigates RGS10 levels in Parkinson's Disease (PD) patients and mice, finding reduced RGS10 in CSF and peripheral immune cells, and showing RGS10 deficiency exacerbates immune dysregulation in chronic systemic inflammation.

The paper investigates shared iron storage and transport deficits in PBMCs from PD and IBD patients, linking them to immune dysfunction and NSAID modulation.

This study shows that the Alzheimer's protective PLCG2-P522R variant affects peripheral macrophage function differently in males and females.

This study uses spatial proteomics to identify subregion-dependent protein changes in dementia variants, revealing disease-specific patterns in cortical layers and white matter.