Christopher D. Scharer

The paper shows that glutaminolysis and mitochondrial metabolism are conditionally crucial for B cell differentiation and cytokine signaling, revealing metabolic regulation of plasma cell generation and cytokine receptor signaling.

This study evaluates the limitations of using EBV-transformed Raji B cells to model inducible NF-κB activation, finding significant discrepancies in signaling responses compared to primary B cells.

This study shows that entinostat enhances CD8+ T cell responses in tumors but only when administered during a specific window after T cell activation, and this effect can be restored by prior oncolytic virus treatment.

The paper investigates Xist RNA's role in X chromosome inactivation dynamics in B cells, finding Xist-dependent and independent epigenetic mechanisms that maintain XCI memory.

This study examines how ocrelizumab affects B and T cell populations in MS patients, revealing changes in B cell subsets and T cell dynamics, along with altered signaling pathways.

The paper shows IRF1 regulates B cell fate by modulating the IRF4-IRF8 axis, promoting pathogenic effector B cells in SLE.

This study identifies circulating HA+ IgDneg memory B cells after LAIV, finding they differ in transcriptional profiles and functional capacity compared to IIV-elicited cells.

This study identifies ATL2 as critical for flavivirus replication by organizing viral replication organelles and limiting immune activation.

This study uses a murine menstruation model to show that NK cell infiltration during endometrial remodeling protects against Chlamydia muridarum infection.

The paper investigates the role of MHCII reduction in protecting mice from alpha-synuclein-induced degeneration and finds that it is insufficient, while showing epigenetic regulation of the Parkinson's HLA locus.

This study identifies the role of Nr4a family nuclear receptors in transcriptional control of T cell tolerance during thymic development, showing their necessity for negative selection and anergy-like programs in self-reactive T cells.

This paper develops a multiscale spatial simulation framework to model the germinal center response, recapitulating key molecular, cellular, and morphological events.

The paper identifies genetic variants in RGS14 that disrupt nuclear shuttling and impair LTP regulation in hippocampal neurons, with variant LR causing nuclear accumulation and loss of function.