Distinct Classes of Gut Bacterial Molybdenum-Dependent Enzymes Produce Urolithins
Minwoo Bae, Xueyang Dong, Julián Ávila-Pacheco, Quyen D. Nguyen, Fechi Inyama, Vayu Maini Rekdal, Clary B. Clish, Emily P. Balskus
This study identifies two distinct molybdenum-dependent enzyme families that produce urolithin A from ellagic acid, linking gut bacterial metabolism to host inflammation in IBD.
Proceedings of the National Academy of Sciences · Dec 24, 2025Peer-reviewedBiochemistry