A chemical biology toolbox to investigate in-cell target engagement and specificity of PRMT5-inhibitors
Elisabeth M. Rothweiler, Jakub Stefaniak, Jennifer Ward, Catherine M. Rogers, Esra Balıkçı, K. Huber
The paper develops chemical biology assays to assess PRMT5 inhibitor target engagement and selectivity, revealing SAM's role in inhibitor binding and confirming the specificity of GSK3326595.
bioRxiv · Jan 20, 2022 · PreprintSystems Biology