Author
University of OxfordORCID 0009-0000-9160-5790Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Alex Au, Abigail Southers, Krzysztof Kuś…·Lidia Vasiljeva
This study shows that the PP1 phosphatase complex coordinates pre-mRNA 3' end processing and RNA polymerase II transcription termination through interactions with PNUTS and Symplekin.
Caner Akıl, Yanchun Peng, Julia McCarthy…·Peijun Zhang
The paper identifies structural differences in TCR recognition of the same pMHC ligand using cryo-EM, showing how similar β chains can pair with different α chains to produce distinct recognition modes.
Anne-Sophie M. C. Marques, Ludwig G. Bauer, Tuan Anh Nguyen…·K. Huber
The paper develops NUDT5 degraders and shows NUDT5 has a non-enzymatic role in 6-TG toxicity, distinct from NUDT15.
Elisabeth M. Rothweiler, Jakub Stefaniak, Jennifer Ward…·K. Huber
The paper develops chemical biology assays to assess PRMT5 inhibitor target engagement and selectivity, revealing SAM's role in inhibitor binding and confirming the specificity of GSK3326595.