K. Huber

This study identifies YbaA as a new ciprofloxacin-binding protein in E. coli using AfBPP and validates its interaction through genetic and biophysical assays.

This study shows bisphosphonates reduce senescence markers and alter proteomes in multiple cell types, suggesting anti-ageing effects beyond bone health.

The paper identifies a non-enzymatic role of NUDT5 in repressing purine de novo synthesis by scaffolding PPAT, with implications for cancer treatment and MTHFD1 deficiency.

The paper develops NUDT5 degraders and shows NUDT5 has a non-enzymatic role in 6-TG toxicity, distinct from NUDT15.

The paper identifies potent nsp3-mac1 inhibitors but finds they do not translate to antiviral activity in cell culture models.

This study develops a small molecule, MC-1, that selectively degrades EP300 over CREBBP, revealing factors governing paralogue-specific degradation and its impact on cancer cell proliferation.

The paper develops chemical biology assays to assess PRMT5 inhibitor target engagement and selectivity, revealing SAM's role in inhibitor binding and confirming the specificity of GSK3326595.

TP-MAP is a software package for analyzing 1D and 2D thermal profiling data to identify hit candidates and explore targets through database integration.

This study develops a method for discovering covalent probes using electrophile fragment screening and identifies selective inhibitors for OTUB2 and NUDT7.

The paper presents a chemical probe collection for studying protein methyltransferases, showing their utility in modulating epigenetic marks and affecting T cell differentiation.