BiochemistrybioRxivPreprint
Mechanistic Insights into TYSM Protein Regulation by mTORC2 in Response to Chemotherapy.
Abdulrahman El Sayed, Maciej Zakrzewski, Remigiusz Adam Serwa, Abdelhalim Azzi
The paper shows that TYMS protein levels change in a biphasic manner after 5-FU treatment, driven by translation rather than transcription, and identifies SIN1 as a key regulator.
DOI 10.1101/2025.05.06.652447