Abdelhalim Azzi

This study identifies SHIP2 as a regulator of TYMS expression and fluoropyrimidine resistance in breast cancer by promoting β-catenin nuclear accumulation and SRC activity.

This study shows SHIP2 exists as a homodimer in cells, and its oligomerization affects interactome and cellular response to sodium arsenate-induced stress granule dynamics.

This study shows that masitinib accumulates in lysosomes via pH-dependent trapping, disrupting autophagy by impairing lysosomal acidification.

The paper shows that TYMS protein levels change in a biphasic manner after 5-FU treatment, driven by translation rather than transcription, and identifies SIN1 as a key regulator.