The paper introduces M3 sensors to measure tissue stress dynamics and shows that abrupt stress increases drive epithelial-mesenchymal transition in cancer.

bioRxiv · Dec 13, 2025 · PreprintBioengineering

TMEM145 is a key component in stereociliary link structures of outer hair cells

Jae Won Roh, Kyung Seok Oh, Jiahn Lee, Yujin Choi, Soomin Kim, Ji Won Hong, Yelim Kim, Hogun Lew, Seung Hyun Jang, Hae-Sol Shin, Jiyeon Ohk, Hosung Jung, Kyoung Yul Seo, Jinwoong Bok, Chul Hoon Kim, Heon Yung Gee

This study identifies TMEM145 as a critical transmembrane protein in OHC stereociliary structures, showing its necessity for structural integrity and auditory function.

bioRxiv · Feb 10, 2025 · PreprintNeuroscience

The founder missense mutation of WFDC2 leads to severe respiratory distress accompanied by bronchiectasis and rhinosinusitis

Jae Won Roh, Jiyoung Oh, Se Jin Kim, Ji Won Hong, Jiyeon Ohk, Hyo Sup Shim, Hyung‐Ju Cho, Ala Woo, Song Yee Kim, Young Ae Kang, Hosung Jung, Kyung Won Kim, Moo Suk Park, Heon Yung Gee

This study identifies a novel WFDC2 mutation causing severe respiratory disease with features similar to cystic fibrosis and primary ciliary dyskinesia in Korean patients.

medRxiv · Nov 16, 2024 · PreprintGenetic & Genomic Medicine

On-site ribosome remodeling by locally synthesized ribosomal proteins in axons

Toshiaki Shigeoka, Max Koppers, Hovy Ho‐Wai Wong, Julie Qiaojin Lin, Roberta Cagnetta, Asha Dwivedy, Janaina De Freitas Nascimento, Francesca W. van Tartwijk, Florian Ströhl, Jean-Michel Cioni, Julia Schaeffer, Mark Carrington, Clemens F. Kaminski, Hosung Jung, William A. Harris, Christine E. Holt

The paper shows that ribosomal proteins are synthesized locally in axons and incorporated into ribosomes in a nucleolus-independent manner, regulated by a novel RNA motif.

Cell Reports · Dec 1, 2019Peer-reviewedNeuroscience