Acidic pH attenuates immune killing through inactivation of perforin
Adrian W. Hodel, Jesse A. Rudd-Schmidt, Tahereh Noori, Christopher J. Lupton, Veronica C T Cheuk, Joseph A. Trapani, Bart W. Hoogenboom, Ilia Voskoboinik
This study shows acidic pH inhibits perforin pore formation, reducing immune cell killing of target cells in solid tumors.
EMBO Reports · Jan 9, 2025Peer-reviewedImmunology