Author

Christopher J. Lupton

Monash UniversityORCID 0000-0002-4617-4853Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Adrian W. HodeliD· 1 shared Ashleigh KroppiD· 1 shared Bart W. HoogenboomiD· 1 shared Bradley A. SpiceriD· 1 shared Chunxiao WangiD· 1 shared Daniel FoxiD· 1 shared Gavin J. KnottiD· 1 shared Hariprasad VenugopaliD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperImmunology

Adrian W. HodelORCID

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2 papers

Recent·Most cited

Inhibiting heme-piracy by pathogenic Escherichia coli using de novo-designed proteins

Daniel Fox, Kazem Asadollahi, Imogen Samuels, Bradley A. Spicer, Ashleigh Kropp, Christopher J. Lupton, Kevin Lim, Chunxiao Wang, Hariprasad Venugopal, Marija Dramićanin, Gavin J. Knott, Rhys Grinter

This study designs de novo proteins to inhibit E. coli's heme extraction from hemoglobin, demonstrating their effectiveness at low nanomolar concentrations.

Nature Communications · Jul 9, 2025Peer-reviewedBiochemistry

Acidic pH attenuates immune killing through inactivation of perforin

Adrian W. Hodel, Jesse A. Rudd-Schmidt, Tahereh Noori, Christopher J. Lupton, Veronica C T Cheuk, Joseph A. Trapani, Bart W. Hoogenboom, Ilia Voskoboinik

This study shows acidic pH inhibits perforin pore formation, reducing immune cell killing of target cells in solid tumors.

EMBO Reports · Jan 9, 2025Peer-reviewedImmunology